Isotopomer Profiling of Leishmania Mexicana Promastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tca Cycle Anaplerosis, Glutamate Synthesis and Growth
نویسندگان
چکیده
Eleanor C. Saunders, William W. Ng , Jennifer M. Chambers, Milica Ng, Thomas Naderer, Jens O. Kroemer, Vladimir A. Likić and Malcolm J. McConville Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria 3010, Australia. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia Running head: carbon metabolism of Leishmania parasites Address correspondence to: Malcolm McConville, 30 Flemington Rd, Parkville, Victoria, 3010, Australia. Tel: 61-3-8344 2342, E-mail: [email protected]
منابع مشابه
Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism
Leishmania parasites alternate between extracellular promastigote stages in the insect vector and an obligate intracellular amastigote stage that proliferates within the phagolysosomal compartment of macrophages in the mammalian host. Most enzymes involved in Leishmania central carbon metabolism are constitutively expressed and stage-specific changes in energy metabolism remain poorly defined. ...
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